Endocrine Abstracts

Introduction: Primary aldosteronism (PA) is characterized by symptoms caused by hypertension and hypokalemia. Some cardiovascular events are found to be more common due to the additional negative effect of aldosterone. The aim of the study was to analyse clinical characteristics of the PA due to adenoma (APA) and to compare the frequency of cardiovascular diseases with those found in adrenal Cushing’ syndrome (CS) and adrenal adenoma associated with essential hypertension...

Introduction: Hyponatremia, defined as a serum sodium concentration below 135 mEq/l, has a heterogeneous etiology, the main endocrine causes includind the syndrome of inappropiate antidiuresis (SIAD), adrenal insufficiency and severe hypothyroidism.Materials and methods: Clinical, hormonal and imaging evaluationAim: To present a case of hyponatremia leading to the diagnosis of a large pituitary tumorCase pres...

Introduction: Intrasellar arachnoid cysts are rare and clinically resemble nonfunctional pituitary adenomas. Arachnoid cysts should be considered in the differential diagnosis of cysts developing in the sellar region, together with cystic pituitary adenoma, craniopharyngioma, epidermoid cysts, and Rathke’s cleft cysts. Symptomatic cysts are operated but can recurr.Case presentation: We present 2 cases of compressive intrasellar arachnoid cysts occur...

Oestrogen has very complex effects on the CNS. It protects neurons from noxious effects of β amyloid in vitro, ameliorates the cerebral metabolism and increases the level of acetylcholine in the basal forebrain and hippocampus. Its beneficial impact in Alzheimer disease may be attributed in part to its antioxidant activity. On the other hand, it has been demonstrated that oestrogens may exhibit genotoxic effects, especially at elevated tissue concentrations. Ther...

Background: Giant prolactinomas are rare pituitary tumours larger than >40 mm in diameter, representing 2–3% of prolactin secreting tumours. Management is challenging especially in male patients, due to resistance to dopamine agonists (DA).Methods: Clinical, hormonal and imaging evaluation and follow-upAim: To describe a case of partially resistant giant prolactinoma in a young male patientCase repor...

Background: PA is a frequent cause (5–13%) of secondary hypertension (HT), yet diagnostic work-up of PA remains challenging.Aim: To describe the characteristics of hypertensive patients diagnosed with PA, biochemical screening (aldosterone:renin ratio/ARR), confirmatory tests, and adrenal CT results.Methods: Clinical, hormonal and imaging evaluation.Results: 13 patients (7M/6F) with PA were 45 yrs (40&#1...

Introduction: PGs are rare neuroendocrine tumours (NETs), slowly growing, derived from the neural crest cells of the autonomous nervous system. Presenting symptoms are related to catecholamine hypersecretion or to mass effect. The optimal approach is dictated by size, symptoms and anatomical relationship of tumours with neurovascular structures.Aim: To describe a patient with bilateral carotid body and mediastinal carotid body PGs....

Background: PA is a clinical syndrome secondary to hemorrhage or infarction of pituitary tumour, presenting with sudden onset headache and oculomotor palsy. PA may be managed conservatively in patients without visual disturbances.Aim: To describe PA patients illustrating typical aspects and peculiarities.Results: Case 1, a 49 years old (yo) male, presented for loss of consciousness in the ER. MRI showed a giant pituitary tumour, wh...

Background: PBMAH is a rare cause of adrenal Cushing’s syndrome, frequently due to aberrant adrenal expression of hormonal receptors.Aim: To describe 6 patients with PBMAH.Methods: Clinical, hormonal and imagistic evaluation.Results: Age at diagnosis of patients (4M/2F) was 50–79 years. One asymptomatic patient was incidentally diagnosed on abdominal CT, two patients had overt Cushing’s (centra...

Adrenal hemangioma is a rare adrenal tumour usually presented as incidental finding in asymptomatic patients. Due to its radiographic features sometimes it’s difficult to differentiate them from other malignant lesions. We present a 55-years-old men admitted to our department with adrenal incidentaloma size 5×4 cm confirmed by MSCT scan. Active phaeochromocythoma was excluded by normal urinary catecholamines. Endocrine evaluations revealed normal midnight cortisol, w...